Diagnosing Difference features interviews with 13 diverse scholars, activists, and artists who identify on the trans spectrum (transgender, transsexual, genderqueer, and gender variant) about the impact and implications of the Gender Identity Disorder (GID) on their lives and communities.

Using the diagnosis as a departure point, the participants debunk myths and misconceptions about transgender identities, challenge stereotypical gender expectations, and offer educative insight into the terms and language used to describe transgender lives. This groundbreaking film is the first to explore the impact of the GID diagnosis on people who identify on the trans spectrum in their own words and images.